Probiotics of L. rhamnosus GG (LGG) protected mice from NAFLD by increasing the abundance of beneficial bacteria, improving gut barrier function and attenuating hepatic inflammation [76], as well as the cholesterol-lowering effect through inhibition of the FXR and FGF15(fibroblast growth factor) signaling pathway [77]. This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatotic liver disease.