TSG (2,3,5,4′-tetrahydroxy-stilbene-2-O-β-d-glucoside) is an active component of the traditional Chinese medicine (TCM) Polygonum multiflorum Thunb, which has shown significant effects in NAFLD prevention by modulating gut microbiota, improving the intestinal mucosal barrier, and suppressing the expression of NF-κB [169]. Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.