Moreover, the LcS supplement dramatically improved the symptoms of NASH induced by MCD such as hepatic histology and serum parameters triglycerides (TG), total cholesterol (TC), as well as the altered expression of hepatic genes and proteins (the mRNA levels of actin alpha/alpha-SMA(α-SMA) and tissue inhibitor of metalloproteinase 1(TIMP-1)). Here, TIMP1 is linked to metabolic dysfunction-associated steatohepatitis.