SGCB and Schnyder corneal dystrophy: This study demonstrates the importance of sGC-cGMP signalling in the leukocyte recruitment that triggers vaso-occlusive events in SCD and provides preliminary data to indicate that sGC activators may provide a potential alternative approach for diminishing leukocyte activation and occlusive mechanisms and, possibly, even the painful vaso-occlusive episodes that characterise SCD.