TNF and Schnyder corneal dystrophy: Leukocyte recruitment was induced by the administration of murine TNF-α (TNF; 0.5 μg, i.p.); in SCD mice, augmented leukocyte adhesion and extravasation occur, leading to vaso-occlusive-like processes in the microcirculation following TNF administration (180 min), when compared to chimeric control mice receiving TNF (CON; C57BL6/C57BL6 transplantation)(Fig. 14b-d).