This virolysis of pancreatic cells may be supported by (1) the inherent susceptibility of pancreatic tissue to influenza virus23 and (2) by the fact that PANC-1 as well as 90% of pancreatic cancers have a KRAS gene mutation,27 leading to a suppression of the antiviral PKR pathway. The gene discussed is KRAS; the disease is familial pancreatic carcinoma.