To address this we analyzed serum levels of two eosinophil granule proteins, ECP and EDN, using pooled data from two independent Phase 2 studies investigating the efficacy of lebrikizumab (an anti-IL-13 monoclonal antibody) in patients with uncontrolled asthma despite maintenance therapy with inhaled corticosteroids (ICS) and a second controller. The gene discussed is RNASE3; the disease is asthma.