Here, we provide a review of the literature describing the role of IL-13 and the ongoing clinical development of therapeutics targeting IL-13 in asthma and other eosinophilic disorders such as atopic dermatitis (AD), eosinophilic esophagitis (EoE), and chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP). Here, IL13 is linked to congenital rubella syndrome.