Disorders associated with dysfunctional Rab GTPase pathways can result from direct dysfunction of Rab proteins or indirectly as a result of defective Rab protein regulators or effectors, and can be genetic or occur during infection due to pathogen-driven processes (for reviews, see references Mitra et al., 2011; Seixas et al., 2013). The gene discussed is AGFG1; the disease is infection.