Interestingly, the analysis of the secondary and tertiary structure of Ps-Tox and Ps-eTox generated by i-tasser revealed a high structural similarity with CARDS toxin, which is present in Mycoplasma pneumonia, and also common with the adhesion domain of B. pertussis toxin and heat-labile enterotoxin alpha chain of E. coli (Supplementary Figure 4). The gene discussed is PRB2; the disease is Mycoplasma pneumoniae pneumonia.