Elevated Kv1.3 expression is detected in a number of human malignancies (27) including breast, colon, and prostate cancer, leukemia (28), melanoma (18), and PDAC (20) Robust evidence demonstrates that Kv1.3 regulates proliferation and cell cycle progression (13), via modulation of the PM potential, a key regulator of proliferation in a number of cell types. This evidence concerns the gene KCNA3 and melanoma.