Specific Kv1.3 blockers that act exclusively on PM Kv1.3, such as Margatoxin or Shk and its analogues have also been reported to block proliferation of T lymphocytes (34), of rat prostate cancer cells (35), of human endothelial cells (36) and of oligodendrocyte progenitor cells (32). This evidence concerns the gene KCNA3 and prostate carcinoma.