It has been demonstrated for example in lung cancer A549-cultured cells that the antiproliferative effect of Margatoxin or of silencing of Kv1.3 expression is mediated via G1-S transition block via a mechanism that involves p21Waf1/Cip1 accumulation and decrease of Cdk4 and cyclin D3 (37). The gene discussed is CCND3; the disease is lung cancer.