Further support of ATRX’s role in mediating chromatin remodeling and potential link with DNA methylation and gene expression has been elucidated by Gibbons and colleagues (18) who have found varied DNA methylation patterns on ATRX syndrome patients on repetitive sequences including rDNA arrays, Y-specific repeat DYZ2, and in a family of subtelomeric repeats (TelBam3.4). Here, ATRX is linked to alpha thalassemia-X-linked intellectual disability syndrome.