Forced resolution of sister telomere cohesion was recommended as a plausible treatment target for ALT-positive tumors within ATRX-mutant/loss gliomas; identifying small peptides/molecules that can bind to macroH2A1 to release tankyrase or interrupting the interaction between macroH2A1 and PARsylated tankyrase 1 through PAR-binding domain of macroH2A1 was a goal the authors suggested for new research (32). Here, TNKS is linked to central nervous system cancer.