Squamous NSCLC with PI3K family gene aberrations had inferior median overall survival (mOS) (8.5 versus 19.1 months, p < 0.0001), higher incidence of brain metastases, especially those with truncated pTEN loss (27 versus 11%, p < 0.0001), higher overall disease burden and genomic heterogeneity between the metastatic and primary tumors (37). The gene discussed is PIK3CA; the disease is non-small cell lung carcinoma.