Phase II trials of ado-trastuzumab emtansine in HER-2 exon 20 or point mutations and HER-2 2+/3+ overexpressed NSCLC reported an RR of 6/18 and 10/49 with mPFS of 4 and 2.7 months, respectively (53, 54). The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.