Lui et al. performed a focused whole-exome analysis of 151 HNSCC tumors (datasets from Stransky et al. and Agrawal et al., plus 45 additional cases [20, 22]), specifically exploring PI3K pathway mutations for therapeutic opportunities [23], This analysis (which did not assess CNAs) indicated the PI3K pathway was the most frequently mutated oncogenic pathway (30.5 % of tumors, 46/151 [23]). Here, PIK3CA is linked to head and neck squamous cell carcinoma.