FANCA and head and neck squamous cell carcinoma: Recent analysis of TCGA data suggested that 15 % (44 out of 291 cases; incompletely congruent with the published TCGA dataset [19]) of HNSCC cases have rare germline truncations, including truncations in several genes important in the Fanconi Anemia Pathway, specifically FANCA and FANCM, which are involved in DNA repair [146, 147].