NFKB1 and non-small cell lung carcinoma: Moreover, in the human non-small cell lung cancer cell line A549, apigenin did not affect the expression of NF-κB but suppressed the translocation of NF-κB from the cytoplasm to the nucleus, which further inhibited target genes, such as Bcl-2, Mcl-1 and Bcl-xL, that block apoptosis.