In human breast cancer cells, falvone of apigenin and luteolin treatment induced FOXO3a expression by suppressing AKT phosphorylation, and subsequently upregulated the expression of FOXO3a target genes of p21WAF1/CIP1 and p27KIP1, which resulted in the inhibition of breast cancer cell proliferation [76]. Here, CDKN1B is linked to breast carcinoma.