Interestingly, HNF4G implies a negative regulation by interacting with FOXA1, RXRA, and HNF4A in the human hepatoma cell line and some studies have showed that interrelationships among FOXA1, FOXA2, HNF4A, and HNF4G affect transcriptional regulation (Tomaru et al., 2009). This evidence concerns the gene FOXA2 and hepatocellular carcinoma.