S1PR5 and Bloom syndrome: Conversely, the BLM-induced regulation of Th2 characteristic transcription factor GATA-3 mRNA differed significantly and was enhanced in the WT versus S1P5−/− mice (WT: 2.0 ± 0.5-fold; S1P5−/−: 0.9 ± 0.3-fold) (Figure 6B).