IL7 and neoplasm: Furthermore, while IL-7 is important for maintaining naive and central memory T cell populations, we found no reduction in memory capacity of donor CAL-101 T cells in either isotype or IL-7-depleted animals, as both groups were equally capable of lysing tumor in mice (Figures 5E,F) and ablating hgp100 antigen bearing splenocytes in our very sensitive in vivo cytotoxicity assay (Figure 5G).