In a study including 149 patients with CHC (and 17 controls) who underwent 12 weeks’ treatment with pegylated IFN-α2b and ribavirin, serum IL-6 levels were significantly higher in CHC patients than in controls, and a high pretreatment IL-6 was associated with lower rates of sustained virologic response (SVR) (52 vs. 79%; P = 0.012) (26). The gene discussed is IFNA1; the disease is cryohydrocytosis.