Patients with cirrhosis had a significant increase in peripheral Th17 cells as increased disease severity (mean: 3.51, 3.94, and 4.46; for Child–Pugh A, B, and C, respectively). The plasma IL-17 concentration was significantly higher in LC patients than in HC (89.76 vs. 61.40; P < 0.01); and also, increased with disease severity. There was an increase in intrahepatic IL-17+ cells, which correlated positively with fibrotic staging scores and clinical progression from CHB to cirrhosis; and most IL-17+ cells were located in the fibrotic areas in the liver. The gene discussed is IL17A; the disease is laryngotracheoesophageal cleft.