IL17A and Cirrhosis: Concerning the progression to cirrhosis, in a study including 173 patients with chronic liver diseases, there was a significant increase in serum IL-17 protein and IL -17 mRNA levels in chronic HBV-related conditions than in HCs (P < 0.001); and patients with cirrhosis exhibited the highest serum IL-17 and IL-17 mRNA in peripheral blood mononuclear cells (PBMCs) (44).