IL17A and Hepatic fibrosis: This role of IL-17 has been reinforced in experimental model where liver fibrosis was inhibited or attenuated in IL-17RA−/− mice exposed to carbon tetrachloride (CCl4) or subjected to bile duct ligation (BDL), associated with reduced mRNA expression of fibrogenic genes (collagen-α1, MMP3, TIMP1, and TGF-β1) (13, 130).