In fact, it has been described that Hepatitis B virus genome integrates in the region located between MYC and PVT-1 in 12.4% of HCCs that develop early after viral infection and that viral integration correlates with upregulation of MYC and PVT-1, and, most probably, with the development of HCC (Yan et al., 2015). This evidence concerns the gene PVT1 and hepatocellular carcinoma.