We also evaluated COC use, obesity or both in relation to cardiovascular risk factors categorized according to the American Heart Association (5), considering HDL-c ≤ 50 mg/dL, CRP ≥ 3 mg/L, fibrinogen ≥ 350 mg/dL, SBP ≥ 140 mmHg, DBP ≥ 90 mmHg, and total cholesterol ≥ 240 mg/dL (Table 2). Here, CRP is linked to obesity due to melanocortin 4 receptor deficiency.