INHA and tuberculosis: Mutated genes that associated with MDR- and XDR-TB are described in Table 2, which are classified as first line anti-TB drugs resistance, that starts with isoniazid resistance; the latter is connected to alterations in the catalase-peroxidase gene (katG), the inhA gene, which encodes in an enzyme involved in mycolic acid biosynthesis (Vilche‘ze and Jacobs, 2007; Riccardi et al., 2009).