The pathways are activated by pro-inflammatory cytokines, neurotrophic factors, neurotransmitters, neural injury, seizure activity, and proteins implicated in neurodegenerative disorders, including HD (Harper and Wilkie, 2003; Memet, 2006), and are upregulated by treatment with 3-nitropropionic acid (3-NPA) or kainate in the striatum, which mimics the pathology caused by mutant Htt (Sugino et al., 2000; Khoshnan et al., 2004). This evidence concerns the gene HTT and Huntington disease.