A long residence time (>1 h) was, e.g., observed for several clinically used antihistamines that bind to the histamine H1 receptor (H1R), an important drug target for the treatment of, e.g., allergic rhinitis (Anthes et al., 2002; Gillard et al., 2002; Slack et al., 2011b; Bosma et al., 2016). The gene discussed is HRH1; the disease is allergic rhinitis.