Besides, the expression of GRP78, CHOP, eIF2α and active cleaved caspase-12 were up-regulated in GBM cells treated with DHA, and pretreatment with MnTMPyP markedly reduced these expression, confirming the critical role of ROS generation in the induction of ER stress pathway of apoptosis (Figures 7C–F). Here, HSPA5 is linked to glioblastoma.