CHRNA7 and Alzheimer disease: In AD brains, its concentration is doubled and in PC12 cell lines drives the production of p-Tau and Aβ (Garcia-Ratés et al., 2016) via its binding to the α7 nicotinic acetylcholine receptor (α7-nAChR) and consequent modulation of calcium entry (Greenfield and Vaux, 2002; Greenfield et al., 2004; Bond et al., 2009; Garcia-Ratés et al., 2016).