DKK1 and neurodegenerative disease: However, there is only one factor Dickkopf 1 (Dkk1), a neurodegenerative factor that serves as an antagonist of the canonical Wnt signaling pathway, has been report to inhibit Wnt activity and induct of neuronal cell death (Caricasole et al., 2004; Scali et al., 2006), the direct role of endogenous Wnt family members play in neurodegenerative diseases is still unknown.