It is known from reductionistic models using adoptive T cell therapies that binding affinities between antigenic peptides and MHC class I and also the binding affinity of the peptide:MHC complex to the corresponding T cell receptor (TCR) are critical determinants of antitumor T cell reactivity and the capability of T cell responses to reject a tumor [94]. The gene discussed is HLA-C; the disease is neoplasm.