Tumor-derived peptides that significantly shape tumor immunity can be divided into five classes of TSAs [81–83]: Overexpressed antigens (e.g. Human epidermal growth factor receptor 2 (HER-2/neu)); differentiation antigens (e.g. melanocyte differentiation antigens); mutational antigens, the vast majority of mutations are unique to each patient, hence the neoantigenome has a largely individual pattern; viral antigens [e.g. derived from Epstein–Barr virus (EBV)], and cancer-testis antigens [e.g. New York esophageal squamous cell carcinoma-1 (NY-ESO-1)]. The gene discussed is ERBB2; the disease is cancer.