The use of TCR transgenic mice with specificities for MHC class I and II as a source of naïve HA-specific T lymphocytes in a model of malignant mesothelioma showed a greatly enhanced T cell response and tumor rejection when CD4 and suboptimal numbers of CD8 lymphocytes were co-transferred, whereas adoptive transfer of CD8 T cells alone was not sufficient to induce tumor remissions [187]. This evidence concerns the gene CD8A and malignant mesothelioma.