Analyses of public gene expression tumor datasets (R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl)) reveal that clinical neuroblastoma specimens express high levels of HIF1A and HIF2A mRNA, while expression of the less-studied HIF3A seems to be detected, if at all, only at extremely low levels (Fig. 2). The gene discussed is HIF1A; the disease is neoplasm.