EPAS1 and neuroblastoma: Whether the HIF-2α–eIF4E2–RBM4-dependent translation mechanism also functions in physiological conditions where HIF-2α is present is an open question but, if so, this might be a major mechanism, together with HIF-2-dependent transcription, to regulate the phenotype of pseudohypoxic cells and, in the case of neuroblastoma, an immature stem cell-like phenotype.