SCN11A and neuropathy: Finally, mutations in NaV1.9 can cause both congenital insensitivity to pain [62] and painful neuropathy [63] in humans, and transgenic mouse work supports a role for NaV1.9 in inflammatory [64], neuropathic [61], and visceral pain [65], suggesting that like NaV1.7 and NaV1.8, NaV1.9 could be targeted to produce pain relief in certain neuropathic pain conditions.