HHEX and obesity due to melanocortin 4 receptor deficiency: In epididymal adipose tissue, obesity affected mRNA levels of 8 genes, including Cdkal1. Cdkal1, Cdc123, Jazf1, Adamts9, and Tmem195 had decreased adipose expression levels in obesity (Supplementary Figure 1A), while levels of Camk1d, Hhex, and Igf2bp2 were increased (Supplementary Figure 1B).