In epididymal adipose tissue, obesity affected mRNA levels of 8 genes, including Cdkal1. Cdkal1, Cdc123, Jazf1, Adamts9, and Tmem195 had decreased adipose expression levels in obesity (Supplementary Figure 1A), while levels of Camk1d, Hhex, and Igf2bp2 were increased (Supplementary Figure 1B). The gene discussed is JAZF1; the disease is obesity due to melanocortin 4 receptor deficiency.