More interestingly, we also observed genes involved in several important tumor‐associated pathways including the ALK pathway (TGFβ2, BMP2, NPPB and others) 15, 16, Lysine degradation (NSD1, SETD7 and others) 17 and ECM‐receptor interaction (CD44, LAMC2 and others) 18 showed dramatically higher levels of expression in HCC‐0010 cells compared with HepG2 cells (Table 2). This evidence concerns the gene NPPB and neoplasm.