Based on the profile of individual genes that showed high expression levels in CML LSCs, as compared to their levels in normal HSCs (see list in Table S1), we focused on three particular genes: PIEZO2, RXFP1, and MAMDC2; so, their expression was determined by quantitative real‐time PCR. This evidence concerns the gene MAMDC2 and chronic myelogenous leukemia, BCR-ABL1 positive.