IRF8 and chronic myelogenous leukemia, BCR-ABL1 positive: One hundred and one genes were upregulated in CML cells (Fig. 4B), including KYNU, MSMO1, RXFP1, CFH, HDC, DHCR24, SCN9A, and CCL5 (Table S2), whereas 97 were downregulated (Fig. 4B), including IRF8, SKIL, KCNA3, ELANE, ARHGAP32, CRHBP, NBPF14, HCAR3, and ID2 (Table S2).