Based on the profile of individual genes that showed high expression levels in CML LSCs, as compared to their levels in normal HSCs (see list in Table S1), we focused on three particular genes: PIEZO2, RXFP1, and MAMDC2; so, their expression was determined by quantitative real‐time PCR. The gene discussed is RXFP1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.