As most ccRCCs (~80–85%) harbor the VHL gene mutation4, 13, 14, we examined AR expression in various RCC cell lines including VHL-wild type (VHL-WT) cell lines SN12-PM6, Caki-1, and ACHN and VHL-mutant (VHL-mut) cell lines A498, SW839, OSRC-2, 769-P, and 786-O cells15–17. The gene discussed is AR; the disease is renal cell carcinoma.