Although most of these genes were highly ranked by at least one other method, two genes were highly ranked and significant only by cDriver, KDM6A and EGR1. The former was recently reported to play a role in a rare aggressive breast cancer37, while the latter was found related to CLL using gene expression and network analysis38, reaffirming their putative role in tumor etiology. This evidence concerns the gene EGR1 and B-cell chronic lymphocytic leukemia.