In agreement with previously published results30, we observe that (a) CCDC88B is genetically linked to susceptibility to IBD, and (b) establish that the level of CCDC88B mRNA in normal CD14+ but not to other cells subsets is regulated by cis-acting variants (eSNPs), (c) detect a significant correlation between eQTLs effects and disease risk, with increased CCDC88B expression associated with increased risk and (d) observe that CCDC88B+myeloid and lymphoid cell subsets infiltrate the lamina propria of CD and UC patients. Here, CCDC88B is linked to inflammatory bowel disease.