Analysis of published genetic association data in CD patients1 revealed significant disease association with SNPs from a 600 kb region overlapping CCDC88B association, with the top marker (rs641168; p = 2.1×10−6 using a logistic regression analysis) located 38.5Kb downstream CCDC88B transcription start site (Fig. 5a). This evidence concerns the gene CCDC88B and Cowden disease.