FOXO3 and rheumatoid arthritis: We found no evidence of our lead SNPs at the CHRNA3/5, LPA and HLA-DQA1/DRB1 loci associating with traits other than smoking behaviour, cardio-metabolism and rheumatoid arthritis, respectively, while finding more pleiotropy at APOE. We also robustly replicated previous work suggesting associations with longevity at CDKN2A/B, SH2B3/ATXN2 and FOXO3A. We found no evidence of association between lifespan and the other 10 loci previously found to suggestively associate with lifespan, despite apparent power to do so.