SNAI2 and lung cancer: Indeed,knockdown of CK2α by RNA interference significantly increased Slug expression,particularly in NatD-KD cells (Fig. 7g–h).Thus, downregulation of Nt-acetylation of histone H4 facilitated nuclearaccumulation of CK2α and it’s binding to histone H4 in lung cancer cells,resulting in increased phosphorylation of histone H4 serine 1.