Indeed,knockdown of CK2α by RNA interference significantly increased Slug expression,particularly in NatD-KD cells (Fig. 7g–h).Thus, downregulation of Nt-acetylation of histone H4 facilitated nuclearaccumulation of CK2α and it’s binding to histone H4 in lung cancer cells,resulting in increased phosphorylation of histone H4 serine 1. The gene discussed is NAA40; the disease is lung cancer.