We found that Nt-acetylation ofhistone H4 antagonizes histone H4 serine 1 phosphorylation (H4S1ph), and thatdownregulation of Nt-acetylation of histone H4 facilitates CK2α binding to histoneH4 in lung cancer cells, resulting in increased H4S1ph and epigenetic reprogrammingto suppress Slug transcription to inhibit EMT. Here, SNAI2 is linked to lung carcinoma.