Next, a combination of purified TGF-β and TNF-α was used to replace immunosupressive tumour supernatants with similar consequences on CAL-1 cells activation by CpG, thus confirming that TGF-β prevents the down-modulation of BAD-LAMP in activated pDCs (Supplementary Fig. 8A, B). The gene discussed is TGFB1; the disease is neoplasm.