Given that Kif2 is involved in asymmetric spindle positioning in invertebrate chordate embryos and morphogenesis of developing mammalian neurites, it may be worthwhile investigating the role played by kinesin-13 family members such as Kif2 and other microtubule depolymerases during UCD as well as other biological processes where microtubule dynamics alter when they encounter the cortex. This evidence concerns the gene KIF2A and urea cycle disorder.