Furthermore, a mutation in SIL/STIL (a human homolog of SAS-5) linked to primary microcephaly (MCPH; Kumar et al. 2009) results in deletion of the Cdh1-dependent destruction motif (KEN-box), leading to deregulated accumulation of STIL protein and centrosome amplification (Arquint and Nigg 2014). This evidence concerns the gene STIL and Primary microcephaly.