Among the 8 cases presenting an altered CEP17 status (>2.0), MLPA found 4 BC (50%) HER2 amplified (mean value ≥1.5), 2 (25%) with a gain (mean value ≥1.3 but <1.5) and the other 2 (25%) non amplified (mean value <1.3). The gene discussed is ERBB2; the disease is breast cancer.