The non-pediatric B-ALL patients are subclassified into four different groups based on age and BCR-ABL1 status: 1) Philadelphia positive (Ph+) ALL adolescent and young adult (aged 15-39 years), 2) Ph+ ALL adult (aged ≥ 40 years), 3) Ph negative (Ph-) ALL adolescent and young adult, and 4) Ph- ALL adult [6]. This evidence concerns the gene ABL1 and acute lymphoblastic leukemia.