There are several types of kinase alteration in BCR-ABL1-like ALL including the rearrangements of CRLF2, rearrangements of ABL tyrosine kinase genes, rearrangements of JAK2 and EPOR, mutations activating Janus kinase and signal transducer and activator of transcription (JAK-STAT) signaling and Ras, and less common kinase alterations (NTRK3 and PTK2B) [81, 82]. Here, CRLF2 is linked to acute lymphoblastic leukemia.