Studies have shown that BCR-ABL1-like B-ALL cases, including cases with gene rearrangement involving ABL1, JAK2, PDGFRB and IL7R and other tyrosine kinase genes, had a poor response to conventional induction chemotherapy but showed sustained responses to TKIs [46, 48, 83, 86]. Here, JAK2 is linked to acute lymphoblastic leukemia.