Genomic profiling study on 154 B-ALL cases revealed most common rearrangements of kinase and cytokine receptor genes involving JAK2, ABL1 (with partners other than BCR), and other genes controlling tyrosine kinases including ABL2, CRLF2, CSF1R, EPOR, NTRK3, PDGFRB, PTK2B, TSLP, or TYK2, and gene mutations involving FLT3, IL7R, or SH2B3 [46]. The gene discussed is IL7R; the disease is acute lymphoblastic leukemia.