The anticancer activity was also studied against breast cancer cell lines by induction of apoptosis using Transferrin-mediated solid lipid nanoparticles (SLNs) of curcumin and the flow cytometric results concluded that the transferrin-mediated SLNs nano-curcumin has potentially gives enhanced anticancer activity of curcumin in breast cancer cell lines in vitro compared to the native or free curcumin [130]. This evidence concerns the gene TF and breast cancer.