BCL2L1 and cancer: The suppression of malignant tumor progression utilizing curcumin revealed the diverse and complex mechanism of action by up-regulation of pro-apoptotic proteins such as Bim, Puma, Bax, Bak, Noxa; downregulation of anti-apoptotic proteins such as XIAP, Bcl-2, and Bcl-xL; growth factor receptors (such as EGFR, HER2) and inhibits the activity of c-Jun N terminal kinase [137], protein tyrosine kinases and protein serine/threonine kinases which reduced the metastatic activity [138].