The ability of BMDMs, stimulated by NTC-Ms, to induce apoptosis of activated T cells was suppressed by an inhibitor of TRIF pathway [65], suggesting that TLR4 ligands in NTC-Ms aroused the apoptosis-inducing capability of Gr-1+CD11b+F4/80+ BMDMs, which was further confirmed by the use of sTLR4 expression vector in palpable tumor [64]. The gene discussed is TLR4; the disease is neoplasm.