The expression of MTDH are presented at a higher levels in TLR4 positive breast cancer cells (MDA-MB-231,MCF-7,and MDA-MB-468) than that in TLR4 negative T47D cell lines after treated with LPS, suggesting the pro-tumor role of TLR4 expressed on tumor cells [92]. The gene discussed is MTDH; the disease is neoplasm.