PRDX1 and prostate carcinoma: Riddell et al. [73] found that the number of vessels and overall vascular areas are increased in prostate cancer (CaP) cell line (PC-3M) shPrx1 tumors, which expressed Prx1 specific shRNA that can lead to a 50% reduction in Prx1 expression, rather than in control group in which tumors expressing non-specific shRNA.