Furthermore, analysis of angiogenetic protein expression in PC-3M tumor lysates showed that VEGF secretion is notably reduced in shPrx1 cells as well as scramble cells, which both were transfected with vectors encoding a MyD88 domain negative(DN) cDNA, suggesting that TLR4-MyD88 pathway is involved in the production of VEGF mediated by Prx1 [73]. This evidence concerns the gene TLR4 and neoplasm.