In this study, we detected the expression of LRG1 and MVD in 312 stage III CRC tissues and matched non-cancerous tissues by immunohistochemistry, analyzed the correlation between clinicopathological parameters and disease-free survival (DFS) and overall survival (OS), assessed the prognostic efficacy of LRG1 in stage III CRC patients, and tested the correlation between LRG1 and VEGF. The gene discussed is VEGFA; the disease is colorectal carcinoma.