Taken together, the purpose of this meta-analysis is to assess the efficacy (e.g., reduction in HbA1c, postprandial glucose, and weight changes) and safety (risk of nausea, vomiting, anorexia and hypoglycemia) of combined use of pramlintide along with insulin in comparison with placebo treatment (placebo and insulin) in patients with type 1 diabetes in clinical randomized controlled trials. The gene discussed is INS; the disease is Hypoglycemia.