CD274 and non-small cell lung carcinoma: In this meta-analysis of randomized trials, we compared the efficacy of PD-1/PD-L1 antibody, first-generation EGFR-TKI and chemotherapy in second- or third-line setting with Bayesian indirect method that allowed for combining direct and indirect evidence, aiming to identify the optimum treatment that could provide best survival benefit for advanced NSCLC patients with WT EGFR tumors.