Each study contained two arms comparing either FOLFOX (bolus and infusional 5-FU, leucovorin and oxaliplatin) or FOLFIRI (bolus and infusional 5-FU, leucovorin and irinotecan), paired with anti-EGFR (cetuximab, panitumumab) or anti-VEGF (bevacizumab) antibodies as first-line therapy for patients with inoperable or metastatic colorectal cancer. The gene discussed is EGFR; the disease is metastatic colorectal cancer.