However, in esophageal squamous cell carcinoma (ESCC), IL-17A overexpression significantly correlated with improved 1-year (OR = 0.34, 95% CI 0.19 to 0.60, P = 0.000), 3-year (OR = 0.48, 95% CI 0.32 to 0.73, P = 0.000) and 5-year OS (OR = 0.53, 95% CI 0.35 to 0.80, P = 0.002). The gene discussed is IL17A; the disease is esophageal squamous cell carcinoma.