SLC12A2 and hepatocellular carcinoma: Based on the dysregulation of NKCC1 in metastatic HCC cell lines and its positive relationship with tumor metastasis in clinical HCC samples, overexpression, RNAi, and activity inhibition experiments were subsequently performed to investigate the relationship between NKCC1 expression and activity with the growth and metastatic ability of HCC cells and its potential value for clinical application.