It was found that there was no significant correlation between PIK3CA amplification and clinicopathological variables (Table 1) available to us, including age (p=0.933), gender (p=0.840), size (p=0.440), location (p=0.117), subtype (p=0.659), international prognosis index (IPI) (p=0.956), performance state (PS), B-symptom (p=0.682), Clinical stage (p=0.298), Extra nodal site (p=0.173), concentration of lactate dehydrogenase (LDH) (p=0.684), therapeutic effects (p=0.552) and treatment (p=0.984), Nor was significant correlation observed for PTEN deficiency (Table 2). Here, PTEN is linked to hyperinsulinemic hypoglycemia, familial, 4.