AFP and neoplasm: It was shown that there were more patients in high EDG2 group with high level of serum AFP (84.5% vs. 62.1%, P = 0.004), larger tumor diameter (69.1% vs. 31.0%, P < 0.001), high Edmonson-Steiner classification (69.1% vs. 20.7%, P < 0.001), advanced TNM stage (78.5% vs. 24.1%, P < 0.001), portal vein invasion (51.9% vs. 13.8%, P = 0.021), and intra-hepatic metastases (23.2% vs. 3.4%, P = 0.014).