Up-regulation of LPA and EDG2 during liver regeneration could accelerate the growth of metastased HCC cells in the remanent liver tissues via PI3K/AKT/mTOR/Skp2/ p27Kip1 signaling and reinforce the migration and invasion abilities of HCC cells via evoking EMT phenotype. This evidence concerns the gene LPAR1 and hepatocellular carcinoma.