The CAR used by Sung Hee Yoon at al. in a study in which CIK cells were redirected against ErBb2 tumor targets contained a different anti-ErbB2 antibody fragment but was also joined to the intracellular portions of CD28 and CD3ζ, as was the case for the CAR construct used in our study [21]. Here, CD28 is linked to neoplasm.