Therefore, we hypothesize, that adding tumor antigen-specificity, such as ErbB2-CAR-specificity, to CIK cells that are already capable of NK cell antitumor activity may result in more precise tumor recognition and enhanced cytotoxicity against STS tumors expressing the ErbB2 antigen, such as RMS, thereby providing minimal toxicity risk. Here, ERBB2 is linked to neoplasm.